Copyright © 2009 John Wiley & Sons, Inc
Published Online: 17 NOV 2009
Print ISBN: 9780470117910
Online ISBN: 9780470485408
DOI: 10.1002/9780470485408
Product Information
70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.
First book to address the discovery and development of antibody therapeutics in their entirety.
Most chapters contain experimental data to illustrate the principles described in them.
Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.
Table of contents
Part I: Antibody Basics
Chapter 1
Therapeutic Monoclonal Antibodies: Past, Present, and Future (pages 1–50)
William R. Strohl
Chapter 2
Antibody Molecular Structure (pages 51–66)
Robyn L. Stanfield and Ian A. Wilson
Chapter 3
Glycosylation of Therapeutic IgGs (pages 67–89)
Yusuke Mimura, Roy Jefferis, Yuka Mimura-Kimura, Jodie Abrahams and Pauline M. Rudd
Chapter 4
Antibody Databases and Tools: The IMGT® Experience (pages 91–114)
Marie-Paule Lefranc
Part II: Antibody Sources
Chapter 5
Human Antibodies from Transgenic Mice (pages 115–150)
Nils Lonberg
Chapter 6
Rabbit Hybridoma (pages 151–168)
Weimin Zhu and Guo-Liang Yu
Chapter 7
Human Antibody Repertoire Libraries (pages 169–188)
David Lowe and Tristan J. Vaughan
Part III: In Vitro Display Technology
Chapter 8
Antibody Phage Display (pages 189–211)
Michael Hust, Holger Thie, Thomas Schirrmann and Stefan D?bel
Chapter 9
Yeast Surface Display (pages 213–237)
Jennifer L. Lahti and Jennifer R. Cochran
Chapter 10
Ribosomal Display (pages 239–253)
George Thom
Chapter 11
Bacterial Display of Antibodies (pages 255–281)
Thomas J. Van Blarcom and Barrett R. Harvey
Chapter 12
Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells (pages 283–307)
Eest S. Smith and Maurice Zauderer
Part IV: Antibody Engineering
Chapter 13
Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques (pages 309–334)
Juan C. Almagro and William R. Strohl
Chapter 14
Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor (pages 335–347)
William F. Dall'Acqua and Herren Wu
Chapter 15
Engineering the Antibody Fc Region for Optimal Effector Function (pages 349–370)
Greg A. Lazar and John R. Desjarlais
Part V: Physiology and in Vivo Biology
Chapter 16
Antibody-Complement Interaction (pages 371–383)
Kileen L. Mershon and Sherie L. Morrison
Chapter 17
Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications (pages 385–415)
Leslie Cope and Tessie McNeely
SummaryPDF(12781K)ReferencesRequest Permissions
Chapter 18
Immunogenicity Screening Using in Silico Methods: Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies (pages 417–437)
Si-Han Hai, Julie A. McMurry, Paul M. Knopf, William Martin and Anne S. De Groot
Chapter 19
Monoclonal Antibody Pharmacokinetics and Pharmacodynamics (pages 439–460)
Christopher R. Gibson, Punam Sandhu and William D. Hanley
Chapter 20
Biodistribution and Imaging (pages 461–482)
Tove Olafsen and Anna M. Wu
Chapter 21
Antibodies and the Blood-Brain Barrier (pages 483–502)
Angela R. Jones and Eric V. Shusta
Part VI: Antibody Characterization
Chapter 22
Determination of Equilibrium Dissociation Constants (pages 503–524)
Robin E. Est, Katrina N. High, Tom R. Glass and Qinjian Zhao
Chapter 23
Molecular and Functional Characterization of Monoclonal Antibodies (pages 525–540)
Qinjian Zhao, Terrance A. Stadheim, Lorenzo Chen and Michael W. Washabaugh
Chapter 24
Characterization of Heterogeneity in Monoclonal Antibody Products (pages 541–554)
Yang Wang, Michael W. Washabaugh and Qinjian Zhao
Part VII: Antibody Expression
Chapter 25
Antibody Expression in Mammalian Cells (pages 555–572)
Fubao Wang, Lorenzo Chen, Neal Connors and Henryk Mach
Chapter 26
Production of Antibodies in Pichia pastoris (pages 573–588)
Juergen H. Nett
Chapter 27
Production of Antibody Fab? Fragments in E. coli (pages 589–622)
David P. Humphreys and Leigh Bowering
Chapter 28
Production of Human Therapeutic Monoclonal Antibodies in Chicken Eggs (pages 623–650)
Lei Zhu and Robert J. Etches
Chapter 29
Production of Antibodies in Plants (pages 651–672)
Kevin M. Cox, Jeffrey T. Regan, Jason D. Sterling, Vincent P. M. Wingate and Lynn F. Dickey
Part VIII: Therapeutic Antibodies
Chapter 30
The Formulation and Delivery of Monoclonal Antibodies (pages 673–709)
Vikas K. Sharma, Hung-Wei Chih, Randall J. Mrsny and Ann L. Daugherty
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Chapter 31
Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates (pages 711–762)
Ningyan Zhang, Brent R. Williams, Ping Lu, Zhiqiang An and Chen-Ni Chin
Chapter 32
Follow-On Protein Products: What, Where, When, How? (pages 763–777)
Brent R. Williams and William R. Strohl
Chapter 33
Monomeric Fc Fusion Molecules (pages 779–795)
Jennifer A. Dumont, Susan C. Low, Robert T. Peters and Alan J. Bitonti
Chapter 34
Radioimmunotherapy: Current Status and Future Directions (pages 797–819)
Neeta Pandit-Taskar and Chaitanya R. Divgi
Chapter 35
Antibody-Drug Conjugate Therapy (pages 821–855)
Stephen C. Alley, Dennis Benjamin and Che-Leung Law
Published Online: 17 NOV 2009
Print ISBN: 9780470117910
Online ISBN: 9780470485408
DOI: 10.1002/9780470485408
Product Information
70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.
First book to address the discovery and development of antibody therapeutics in their entirety.
Most chapters contain experimental data to illustrate the principles described in them.
Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.
Table of contents
Part I: Antibody Basics
Chapter 1
Therapeutic Monoclonal Antibodies: Past, Present, and Future (pages 1–50)
William R. Strohl
Chapter 2
Antibody Molecular Structure (pages 51–66)
Robyn L. Stanfield and Ian A. Wilson
Chapter 3
Glycosylation of Therapeutic IgGs (pages 67–89)
Yusuke Mimura, Roy Jefferis, Yuka Mimura-Kimura, Jodie Abrahams and Pauline M. Rudd
Chapter 4
Antibody Databases and Tools: The IMGT® Experience (pages 91–114)
Marie-Paule Lefranc
Part II: Antibody Sources
Chapter 5
Human Antibodies from Transgenic Mice (pages 115–150)
Nils Lonberg
Chapter 6
Rabbit Hybridoma (pages 151–168)
Weimin Zhu and Guo-Liang Yu
Chapter 7
Human Antibody Repertoire Libraries (pages 169–188)
David Lowe and Tristan J. Vaughan
Part III: In Vitro Display Technology
Chapter 8
Antibody Phage Display (pages 189–211)
Michael Hust, Holger Thie, Thomas Schirrmann and Stefan D?bel
Chapter 9
Yeast Surface Display (pages 213–237)
Jennifer L. Lahti and Jennifer R. Cochran
Chapter 10
Ribosomal Display (pages 239–253)
George Thom
Chapter 11
Bacterial Display of Antibodies (pages 255–281)
Thomas J. Van Blarcom and Barrett R. Harvey
Chapter 12
Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells (pages 283–307)
Eest S. Smith and Maurice Zauderer
Part IV: Antibody Engineering
Chapter 13
Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques (pages 309–334)
Juan C. Almagro and William R. Strohl
Chapter 14
Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor (pages 335–347)
William F. Dall'Acqua and Herren Wu
Chapter 15
Engineering the Antibody Fc Region for Optimal Effector Function (pages 349–370)
Greg A. Lazar and John R. Desjarlais
Part V: Physiology and in Vivo Biology
Chapter 16
Antibody-Complement Interaction (pages 371–383)
Kileen L. Mershon and Sherie L. Morrison
Chapter 17
Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications (pages 385–415)
Leslie Cope and Tessie McNeely
SummaryPDF(12781K)ReferencesRequest Permissions
Chapter 18
Immunogenicity Screening Using in Silico Methods: Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies (pages 417–437)
Si-Han Hai, Julie A. McMurry, Paul M. Knopf, William Martin and Anne S. De Groot
Chapter 19
Monoclonal Antibody Pharmacokinetics and Pharmacodynamics (pages 439–460)
Christopher R. Gibson, Punam Sandhu and William D. Hanley
Chapter 20
Biodistribution and Imaging (pages 461–482)
Tove Olafsen and Anna M. Wu
Chapter 21
Antibodies and the Blood-Brain Barrier (pages 483–502)
Angela R. Jones and Eric V. Shusta
Part VI: Antibody Characterization
Chapter 22
Determination of Equilibrium Dissociation Constants (pages 503–524)
Robin E. Est, Katrina N. High, Tom R. Glass and Qinjian Zhao
Chapter 23
Molecular and Functional Characterization of Monoclonal Antibodies (pages 525–540)
Qinjian Zhao, Terrance A. Stadheim, Lorenzo Chen and Michael W. Washabaugh
Chapter 24
Characterization of Heterogeneity in Monoclonal Antibody Products (pages 541–554)
Yang Wang, Michael W. Washabaugh and Qinjian Zhao
Part VII: Antibody Expression
Chapter 25
Antibody Expression in Mammalian Cells (pages 555–572)
Fubao Wang, Lorenzo Chen, Neal Connors and Henryk Mach
Chapter 26
Production of Antibodies in Pichia pastoris (pages 573–588)
Juergen H. Nett
Chapter 27
Production of Antibody Fab? Fragments in E. coli (pages 589–622)
David P. Humphreys and Leigh Bowering
Chapter 28
Production of Human Therapeutic Monoclonal Antibodies in Chicken Eggs (pages 623–650)
Lei Zhu and Robert J. Etches
Chapter 29
Production of Antibodies in Plants (pages 651–672)
Kevin M. Cox, Jeffrey T. Regan, Jason D. Sterling, Vincent P. M. Wingate and Lynn F. Dickey
Part VIII: Therapeutic Antibodies
Chapter 30
The Formulation and Delivery of Monoclonal Antibodies (pages 673–709)
Vikas K. Sharma, Hung-Wei Chih, Randall J. Mrsny and Ann L. Daugherty
SummaryPDF(251K)ReferencesRequest Permissions
Chapter 31
Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates (pages 711–762)
Ningyan Zhang, Brent R. Williams, Ping Lu, Zhiqiang An and Chen-Ni Chin
Chapter 32
Follow-On Protein Products: What, Where, When, How? (pages 763–777)
Brent R. Williams and William R. Strohl
Chapter 33
Monomeric Fc Fusion Molecules (pages 779–795)
Jennifer A. Dumont, Susan C. Low, Robert T. Peters and Alan J. Bitonti
Chapter 34
Radioimmunotherapy: Current Status and Future Directions (pages 797–819)
Neeta Pandit-Taskar and Chaitanya R. Divgi
Chapter 35
Antibody-Drug Conjugate Therapy (pages 821–855)
Stephen C. Alley, Dennis Benjamin and Che-Leung Law