Handy D.E., Loscalzo J. Redox Regulation of Mitochondrial Function

Статья. Опубликована в журнале Antioxidants & Redox signaling, 2012, volume 16, №11, р. 1323-1367 Замечательный последовательный обзор роли окислительно - восстановительного потенциала в регуляции функции митохондрий и клетки вообще, значения свободных радикалов во внутреклеточном сигнализировании. Детально освещено функционирование естественных антиоксидантных механизмов. Redox-dependent processes influence most cellular functions, such as differentiation, proliferation, and apoptosis. Mitochondria are at the center of these processes, as mitochondria both generate reactive oxygen species (ROS) that drive redox-sensitive events and respond to ROS-mediated changes in the cellular redox state. In this review, we examine the regulation of cellular ROS, their modes of production and removal, and the redoxsensitive targets that are modified by their flux. In particular, we focus on the actions of redox-sensitive targets that alter mitochondrial function and the role of these redox modifications on metabolism, mitochondrial biogenesis, receptor-mediated signaling, and apoptotic pathways. We also consider the role of mitochondria in modulating these pathways, and discuss how redox-dependent events may contribute to pathobiology by altering mitochondrial function.