Banoub J.H., Limbach P.A. (Eds.) Mass Spectrometry of Nucleosides and Nucleic Acids

CRC Press, Taylor & Francis Group, 2010, 492 pages

Assembling the work of an inteational panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS).

Overview of Recent Developments in the Mass Spectrometry of Nucleic Acid and Constituents
Mass Spectrometric Analysis of Deoxyinosines
Tandem Mass Spectrometry of Nucleic Acids
Mass Spectrometric Application in the Study of Cyclic Nucleotides in Biochemical Signal Transduction
Analysis of Urinary Modified Nucleosides by Mass Spectrometry
Mass Spectrometric Determination of DNA Adducts in Human Carcinogenesis
Sequence Distribution of Nucleobase Adducts Studied by Isotope Labeling of DNA–Mass Spectrometry
Electrospray Mass Spectrometry of Noncovalent Complexes between Small Molecule Ligands and Nucleic Acids
Electrospray Ionization–Mass Spectrometry for the Investigation of Protein–Nucleic Acid Interactions
Characterization of Noncovalent Complexes of Nucleic Acids with Peptides and Proteins by Mass Spectrometry
MALDI-TOF Detection of Specifi c Noncovalent Complexes of Highly Acidic Biomolecules with Pyrenemethylguanidinium
Quantitative Identification of Nucleic Acids via Signature Digestion Products Detected Using Mass Spectrometry
Electrospray Ionization Mass Spectrometry for the Direct Analysis of Modifi ed Nucleosides in Small RNAs
LC-MS/MS for the Examination of the Cytotoxic and Mutagenic Properties of DNA Lesions In Vitro and In Vivo
Influence of Metal Ions on the Structure and Reactivity of Nucleic Acids