Printed in Germany, Springer-Verlag, Berlin, Heidelberg, 2005, 263
p.
Contents
General notes on synthesis
Soluble polyvinylpyrrolidone (Povidone)
Insoluble polyvinylpyrrolidone (Crospovidone)
Vinylpyrrolidone-vinyl acetate copolymer (Copovidone)
Soluble polyvinylpyrrolidone (Povidone)
Structure, product range, synonyms
Product properties
Description, specifications, pharmacopoeias
Solubility, dissolution
Viscosity, K-value
Particle size, particle structure, bulk density
Hygroscopicity
Molecular weight
Complexation, chemical reactions
Osmotic pressure, sterilization by filtration (low-molecular povidone)
Stability, storage
Analytical methods for povidone
Qualitative and quantitative methods of determination
Methods for the determination of the K-valueand molecular weight
Methods for the determination of purity
Determination of povidone in preparations
Applications of povidone
General properties
Binders for tablets, granules and hard gelatin capsules
Improvement of the dissolution rate and bioavailability of drugs
Tablet coatings
Improvement of the solubility of drugs (solubilization)
Suspensions, dry syrups and instant granules
Applications in ophthalmic solutions
Sustained-release preparations
Miscellaneous applications
Insoluble polyvinylpyrrolidone (Crospovidone)
Structure, product range, synonyms
Properties of crospovidone
Description, specifications, pharmacopoeias
Particle size, bulk density
Specific surface area, water absorption
Swelling
Complexation, chemical interaction
Stability, storage, packaging
Analytical methods for crospovidone
Qualitative and quantitative methods of determination
Methods for the determination of purity
Determination of complexation capacity with salicylic acid
Quantitative determination of crospovidone in preparations
Applications of crospovidone
General application properties
Crospovidone as disintegrant and dissolution agent for tablets, granules and hard gelatin capsules
Improvement of the dissolution and bioavailability of drugs with crospovidone
Micronized crospovidone of low bulk density as a stabilizer for oral and topical suspensions
Micronized crospovidone as an active substance
Miscellaneous applications
Vinylpyrrolidone-vinyl acetate copolymer (Copovidone)
Structure, synonyms
Product properties
Description, specification, pharmacopoeias
Solubility
Viscosity, K-value, molecular weight
Physical properties of the powder
Stability, storage, packaging
Analytical methods
Qualitative and quantitative methods of determination
Methods for the determination of purity
Determination of copovidone in preparations
Applications of copovidone
General notes
Binder for tablets, granulates and hard gelatin capsules
Tablet coatings
Film-forming agent in sprays
Matrix-forming agent in sustained-release and fast-release dosage forms
Transdermal and transmucosal systems
Registration and toxicological data
Registration
Pharmaceutical products
Food
Toxicological data
Povidone and Crospovidone
Copovidone
Literature references
Alphabetical index
Contents
General notes on synthesis
Soluble polyvinylpyrrolidone (Povidone)
Insoluble polyvinylpyrrolidone (Crospovidone)
Vinylpyrrolidone-vinyl acetate copolymer (Copovidone)
Soluble polyvinylpyrrolidone (Povidone)
Structure, product range, synonyms
Product properties
Description, specifications, pharmacopoeias
Solubility, dissolution
Viscosity, K-value
Particle size, particle structure, bulk density
Hygroscopicity
Molecular weight
Complexation, chemical reactions
Osmotic pressure, sterilization by filtration (low-molecular povidone)
Stability, storage
Analytical methods for povidone
Qualitative and quantitative methods of determination
Methods for the determination of the K-valueand molecular weight
Methods for the determination of purity
Determination of povidone in preparations
Applications of povidone
General properties
Binders for tablets, granules and hard gelatin capsules
Improvement of the dissolution rate and bioavailability of drugs
Tablet coatings
Improvement of the solubility of drugs (solubilization)
Suspensions, dry syrups and instant granules
Applications in ophthalmic solutions
Sustained-release preparations
Miscellaneous applications
Insoluble polyvinylpyrrolidone (Crospovidone)
Structure, product range, synonyms
Properties of crospovidone
Description, specifications, pharmacopoeias
Particle size, bulk density
Specific surface area, water absorption
Swelling
Complexation, chemical interaction
Stability, storage, packaging
Analytical methods for crospovidone
Qualitative and quantitative methods of determination
Methods for the determination of purity
Determination of complexation capacity with salicylic acid
Quantitative determination of crospovidone in preparations
Applications of crospovidone
General application properties
Crospovidone as disintegrant and dissolution agent for tablets, granules and hard gelatin capsules
Improvement of the dissolution and bioavailability of drugs with crospovidone
Micronized crospovidone of low bulk density as a stabilizer for oral and topical suspensions
Micronized crospovidone as an active substance
Miscellaneous applications
Vinylpyrrolidone-vinyl acetate copolymer (Copovidone)
Structure, synonyms
Product properties
Description, specification, pharmacopoeias
Solubility
Viscosity, K-value, molecular weight
Physical properties of the powder
Stability, storage, packaging
Analytical methods
Qualitative and quantitative methods of determination
Methods for the determination of purity
Determination of copovidone in preparations
Applications of copovidone
General notes
Binder for tablets, granulates and hard gelatin capsules
Tablet coatings
Film-forming agent in sprays
Matrix-forming agent in sustained-release and fast-release dosage forms
Transdermal and transmucosal systems
Registration and toxicological data
Registration
Pharmaceutical products
Food
Toxicological data
Povidone and Crospovidone
Copovidone
Literature references
Alphabetical index