Эта книга содержит информацию о клинической картине, гистопатологии
при лекарственно-индуцированной гепатотоксичности. Рассматривает
поражения печени, которые могут быть вызваны лекарственными
препаратами и токсинами. Указываются факторы, которые
предрасполагают к проявлению токсичности отдельных препаратов,
предлагаются стратегии для мониторинга пациентов с риском
токсичности, а также предоставляет информацию профилактических
мероприятиях.
Contents
Preface
Contributors
Mechanisms
Drug-Induced Liver Disorders: Introduction and Overview
The Role of Cytochrome P450s in Drug-Induced Liver
Oxidative Stress, Antioxidant Defense, and Liver Injury
Hepatotoxicity Due to Mitochondrial Injury
Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity
The Role of Membrane Transport in Drug-Induced Hepatotoxicity and Cholestasis
Immunological Mechanisms in Liver Injury
Mechanistic Role of Acyl Glucuronides
Nonparenchymal Cells, Inflammatory Macrophages, and Hepatotoxicity
Roles of Cytokines and Growth Factors in Liver Regeneration, Repair,and Fibrosis After Liver Injury
Diagnosis and Management
Clinicopathological Pattes of Drug-Induced Liver Disease
Histopathology of Drug-Induced Liver Disease
Hepatotoxicity of Specific Drugs
Mechanisms of Acetaminophen-Induced Liver Disease
Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity
Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs
Nonsteroidal Anti-Inflammatory Drugs: Pathology and ClinicalPresentation of Hepatotoxicity
Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents
Anticonvulsant Agents
Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse
Antibacterials and Antifungal Agents
Antituberculous Agents–Induced Liver Injury
Hepatic Injury from Antiviral Agents
Hepatotoxicity of Cardiovascular and Antidiabetic Drugs
Cancer Chemotherapy
Immunomodulating Agents and the Transplant Situation
Methotrexate Controversies
Adverse Effects of Hormones and Hormone Antagonists on the Liver
Alteative Medicine, Vitamins, and Natural Hepatotoxins
Occupational and Environmental Hepatotoxicity
Regulatory Perspectives
Index
Contents
Preface
Contributors
Mechanisms
Drug-Induced Liver Disorders: Introduction and Overview
The Role of Cytochrome P450s in Drug-Induced Liver
Oxidative Stress, Antioxidant Defense, and Liver Injury
Hepatotoxicity Due to Mitochondrial Injury
Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity
The Role of Membrane Transport in Drug-Induced Hepatotoxicity and Cholestasis
Immunological Mechanisms in Liver Injury
Mechanistic Role of Acyl Glucuronides
Nonparenchymal Cells, Inflammatory Macrophages, and Hepatotoxicity
Roles of Cytokines and Growth Factors in Liver Regeneration, Repair,and Fibrosis After Liver Injury
Diagnosis and Management
Clinicopathological Pattes of Drug-Induced Liver Disease
Histopathology of Drug-Induced Liver Disease
Hepatotoxicity of Specific Drugs
Mechanisms of Acetaminophen-Induced Liver Disease
Acetaminophen: Pathology and Clinical Presentation of Hepatotoxicity
Mechanisms Underlying the Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs
Nonsteroidal Anti-Inflammatory Drugs: Pathology and ClinicalPresentation of Hepatotoxicity
Mechanism, Pathology, and Clinical Presentation of Hepatotoxicity of Anesthetic Agents
Anticonvulsant Agents
Hepatotoxicity of Psychotropic Drugs and Drugs of Abuse
Antibacterials and Antifungal Agents
Antituberculous Agents–Induced Liver Injury
Hepatic Injury from Antiviral Agents
Hepatotoxicity of Cardiovascular and Antidiabetic Drugs
Cancer Chemotherapy
Immunomodulating Agents and the Transplant Situation
Methotrexate Controversies
Adverse Effects of Hormones and Hormone Antagonists on the Liver
Alteative Medicine, Vitamins, and Natural Hepatotoxins
Occupational and Environmental Hepatotoxicity
Regulatory Perspectives
Index