Иммунология и аллергология
  • формат pdf
  • размер 16.26 МБ
  • добавлен 01 сентября 2011 г.
Kishore, Uday (Ed.) Target Pattern Recognition in Innate Immunity (2009, Vol.653)
Target patte recognition in innate immunity is responsible for the immediate, usually protective, responses shown against invading microorganisms, and it is the principal feature of self and non-self recognition by virtue of the recognition of structures on the microbial pathogens, which are not found on host cells. This is an area that has been very actively researched, over approximately the past 12 years, and therefore this volume provides a timely comprehensive, and up to date, summary of the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events.

The Toll-like receptors, first described in Drosophila and now well-characterised on human cells, provide an excellent demonstration of the wide range of different microbial products recognised by this family of receptors and of the signalling pathways which are triggered thus leading to induction of inflammatory cytokines and the activation of genes producing antimicrobial products. In addition, several cell surface proteins involved in target patte recognition have been described on the surfaces of macrophages (macrophage mannose receptor and macrophage scavenger receptors), and on dendritic cells (DEC205), and to be involved with the uptake and clearance of whole microorganisms and polyanioic ligands. Patte recognition is also utilised by intracellular receptors, with NOD-like receptors in the cytosol recognizing microbial molecules and activating the production of inflammatory cytokines or pathways that induce the production of inflammatory molecules. Secreted proteins, such as the pentraxins, which includes the acute phase reacting, C-reactive protein (CRP) and serum amyloid protein (SAP), and the collectins (mannan binding lectin, lung surfactant protein A and D) and ficolins can also readily recruit killing and clearance systems. Indeed, the serum complement system, which is one of the major defence systems in the bloodstream, is efficiently activated by CR P on its binding to the phosphocholine groups of microbial phospholipids—and the subsequent interaction of the bound CR P with C1q—to give classical pathway activation, or MBL, or ficolin, binding to arrays of mannose or N-acetyl-glucosamine residues, respectively, on the surfaces of microorganisms—to give lectin pathway activation. Also, in addition to the activation and clearance events associated with complement activation by some of the secreted patte recognition receptors, it is accepted that all these patte recognition receptors can generally accelerate the uptake and clearance of microbes via phagocytic cells.

In view of the growing interest in the cross-talk between innate and adaptive immunity, a thorough understanding of the initial recognition and triggering events, mediated via innate immune receptors, as addressed in this volume, is clearly very useful in helping to also fully understand the mechanisms of activation and control of the adaptive immune system—and to allow a full assessment of the relative roles played by innate immunity and adaptive immunity against a particular infection in higher organisms.

TABLE OF CONTENTS


1. Macrophage Patte Recognition Receptors in Immunity, Homeostasis and Self Tolerance

Subhankar Mukhopadhyay, Annette Pl?ddemann, and Siamon Gordon

Abstract
Introduction
The Scavenger Receptor Family
Class A Scavenger Receptors
SR-A (SR-AI/II)
MARCO
SRCL-I/ CLP-I
C-Type Lectin Receptors
C-Type Lectins with a Single CRD
C-Type Lectins with Multiple CRDs
NK-Like C-Type Lectin-Like Receptors
Self Tolerance in Innate Immunity
Conclusion


2. Patte Recognition by Toll-Like Receptors


Stefan Bauer, Thomas M?ller, and Svetlana Hamm

Abstract
Introduction
Toll-Like Receptors and Their Ligands
Bacterial Recognition by TLRs
Viral Recognition by TLRs
Recognition of Fungi and Protozoan Parasites by TLRs
Cellular Localization of TLRs
Recognition of Endogenous Ligands by TLRs and Involvement in Autoimmunity
TLR Signaling
Interferon Production by TLRs
TLR Structure
TLR Expression in Cells of the Adaptive Immune System
Conclusion


3. NOD-Like Receptors—Pivotal Guardians of the Immunological Integrity of Barier Organs


Philip Rosenstiel and Stefan Schreiber

Abstract
Introduction
NOD-Like Receptors—Phylogenetically Ancient Molecular Platforms of the Innate Immune System
Modular Domain Structure
NLRs and the Recent Rise of Barrier Diseases
Plasticity of NLR Function
Conclusions


4. Toll-Like Receptors and NOD-Like Receptors: Domain Architecture and Cellular Signalling

Tanja Langefeld, Walid Mohamed, Rohit Ghai, and Trinad Chakraborty

Abstract
Introduction
Toll-Like Receptors
Myd88 Dependent TLR Signalling
Myd88 Independent TLR Signalling
Nod-Like Receptors
Conclusions


5. Humoral Patte Recognition Molecules: Mannan-Binding Lectin and Ficolins

Steffen Thiel and Mihaela Gadjeva

Abstract
Introduction
Biochemistry
Biology
Conclusion


6. Lung Surfactant Proteins A and D as Patte Recognition Proteins

Patrick Waters, Mudit Vaid, Uday Kishore, and Taruna Madan

Abstract
Introduction
Collectin Structure Overview
N-Terminal Region
Collagen Region
Neck Region
Carbohydrate Recognition Domain (CRD)
SP-A and SP-D Bind Lipid via Their CRDs
Calcium Ions Are Required for CRD Function
Factors Affecting Interaction with Polysaccharides
Directing the Immune Response
Specific Examples of SP-A and SP-D as PRRs
Fungus and Yeast
Viruses
SP-A and SP-D in Protection against Allergens and Pulmonary
Hypersensitivity
Phenotype and Susceptibility of SP-A and SP-D Gene Deficient Mice
Conclusion


7. Patte Recognition by Pentraxins

Alok Agrawal, Prem Prakash Singh, Barbara Bottazzi, Cecilia Garlanda, and Alberto Mantovani

Abstract
Pentraxins
Short Pentraxins: CRP and SAP
Long Pentraxin: PTX3
Conclusions


8. Target Patte Recognition by Complement Proteins of the Classical and Alteative Pathways

Yu-Hoi Kang, Lee Aun Tan, Maria V. Carroll, Madeleine E. Gentle, and Robert B. Sim

Abstract
The Complement System
C1q and C1 Structure
Biosynthesis of C1q
Target Recognition by C1q
Structural Basis of C1q Binding to Targets
C1q Receptors
C1q across the Animal Kingdom
Properdin and the Alteative Pathway


9. Patte Recognition in Phagocytic Clearance of Altered Self

Yoshinobu Nakanishi, Peter M. Henson, and Akiko Shiratsuchi

Abstract
Roles and Mechanisms of Phagocytosis
Recognition of Altered Self by Phagocytes
Consequences of Phagocytic Clearance of Apoptotic Cells
Fate of Necrotic Cells or Cells Dying by Other Modes
Concluding Remarks


10. Structural Basis of Patte Recognition by Innate Immune Molecules

Eamon P. McGreal

Abstract
Introduction
Molecules Containing Leucine Rich Repeats (LRRs)
Carbohydrate Recognition by C-Type Lectin and C-Type Lectin-Like Molecules
Emerging Innate Immune Patte Recognition Molecules
Conclusions


11. Lessons from the Fly: Patte Recognition in Drosophila melanogaster

Subhamoy Pal and Louisa P. Wu

Introduction
The Immune Response in the Fly
The Patte Recognition Receptors
Conclusion


12. Immune Recognition of Plasmodium-Infected Erythrocytes

Damien V. Cordery and Britta C. Urban

Malaria
Clinical Immunity to P. falciparum Infection
Involvement of Patte Recognition Receptors in Plasmodium Infection
Recognition of Plasmodium-iRBCs by Toll-Like Receptors
Recognition of Plasmodium-iRBCs by Scavenger Receptors
Conclusions and Perspectives


13. Innate Immune Recognition in Tuberculosis Infection

Anthony G. Tsolaki

Abstract
Introduction
Receptor-Mediated Phagocytosis of M. tuberculosis
Complement Receptors
Mannose Receptors
Scavenger Receptors
Survival of M. tuberculosis inside the Phagosome
Immune Recognition of M. tuberculosis
Cytokines Induced in Response to M. tuberculosis Infection
Concluding Remarks
Смотрите также

Контрольная работа - Иммунитет детского организма. Иммунное отношение матери и плода

Контрольная работа
  • формат docx
  • размер 38.19 КБ
  • добавлен 04 января 2012 г.
ТюмГУ, Тюмень/Россия, к. б. н., доцент Фатеева Н. М., 19 стр., 2009 г., 2 курс Дисциплина "Иммунитет и здоровье" Введение Иммунитет Возрастные особенности иммунитета детей Критические периоды развития иммунобиологической реактивности Повышение иммунитета ребенка Иммунное отношение матери и плода Заключение Литература

Хаитов Р.М. Аллергология и иммунология. Национальное руководство

  • формат pdf
  • размер 94.27 МБ
  • добавлен 28 марта 2011 г.
Издательство: ГЭОТАР-Медиа Год: 2009 Национальное руководство по аллергологии и иммунологии представляет собой фундаментальный труд отражающий современный уровень развития этой области медицины. Работа над изданием проводилась под эгидой Российской ассоциации аллергологов и клинических иммунологов при активном участии сотрудников крупнейших научно-исследовательских учреждений России. Благодаря обьединению в авторский коллектив большинства ведущи...

Черношей Д.А., Кирильчик Е.Ю., Титов Л.П. Аллергия. Медиаторный тип ГНТ. Методы диагностики

  • формат doc
  • размер 1.97 МБ
  • добавлен 19 октября 2011 г.
БГМУ Учебно-методическое пособие Минск БГМУ 2009. - 29 с. Список сокращений Введение ГНТ I медиаторного (реагинового) типа Методы диагностики аллергических заболеваний Аллергоанамнез Объективное обследование больного Методы диагностики in vivo Методы диагностики in vitro Литература

Janeway С. Immunobiology

  • формат pdf
  • размер 17.4 МБ
  • добавлен 28 августа 2011 г.
Product Details Paperback: 600 pages Publisher: Garland Science; 5 edition (June 21, 2001) Language: English ISBN-10: 081533642X ISBN-13: 978-0815336426 Editorial Reviews Review Of previous editions: "Treats the subject of immunology with freshness and vigor and enthusiasm . Abundantly illustrated. As up to date as a textbook can be . clearly written and complete." New England Journal of Medicine "One of the best general immunology textbooks a...

Lydyard Peter M., Whelan A., Fanger Michael W. Instant Notes in Immunology

  • формат djvu
  • размер 5.21 МБ
  • добавлен 27 октября 2011 г.
Published: 15/06/2000 Publisher: Garland Publishing Inc ISBN: 9780387915869 Concise yet comprehensive, Instant Notes in Immunology provides easy access to core areas in immunology. Topics covered include the immune system, cells and development of the immune system, lymphoid organs and tissues, antibodies, cytokines, antigen recognition, immune system response and regulation, infection, tumor immunology, transplant rejection, vaccination, immune...

Rabson A., Roitt I.M., Delves P.J. Really Essential Medical Immunology

  • формат pdf
  • размер 4.94 МБ
  • добавлен 31 августа 2010 г.
Really Essential Medical Immunology. Paperback: 224 pages. Publisher: Wiley-Blackwell; 2 edition (November 19, 2004). Language: English. ISBN-10: 1405121157. ISBN-13: 978-1405121156. This new edition of Really Essential Medical Immunology builds on the success of the first edition and includes a fresh contemporary look and easy to navigate feel, with fully updated content and materials. Really Essential Medical Immunology is a concise, manageabl...

Rich R.R. Clinical Immunology Principles and Practice 2008

  • формат pdf
  • размер 124.31 МБ
  • добавлен 16 мая 2011 г.
Hardcover: 1530 pages Publisher: Mosby; 3 edition (April 15, 2008) Language: English "The authors and editors have taken pains to make the text clinician-friendly.The page layout is pleasing to the eye and easy to use. " - JAMA, review of the last edition ".the basics of immunology are rapidly expounded with summaries, tables, and diagrams providing a depth of information on immunological mechanisms in an eye-catching format. The editors and con...

Roitt's Essential Immunology 10th ed

  • формат pdf
  • размер 81.39 МБ
  • добавлен 09 июня 2010 г.
Издательство: Blackwell science. Издание: десятое. Год издания: 2001, переиздание 2003, 2004. ISBN: 0-632-05902-8. Количество страниц: 494. We live in a potentially hostile world filled with a bewildering array of infectious agents of diverse. shape, size, composition and subversive character which would very happily use us as rich. sanctuaries for propagating their 'selfish genes' had we not also developed a series of defense. mechanisms at leas...

Shetty Nandini (ed.). Immunology Introductory textbook (2003)

  • формат pdf
  • размер 3.47 МБ
  • добавлен 10 июня 2010 г.
Pages: 224. Publisher: New Age International (P) Ltd. (2003). Editor: Shetty Nandini (ed.) ISBN-10: 8122406408. ISBN-13: 978-8122406405. As textbooks and journals of immunology grow in size and number and the explosion of. information floods the libraries, students often find themselves overwhelmed by the volume of. reading required to understand basic concepts. Assimilating a fast changing, ever expanding. subject like immunology can be a daunti...

William E.Paul. Fundamental Immunology 6th ed. 2008

  • формат chm
  • размер 67.65 МБ
  • добавлен 10 июня 2010 г.
Hardcover: 1632 pages. Publisher: Lippincott Williams & Wilkins; Sixth Edition edition (May 1, 2008). Language: English. Editor: William E.Paul MD. ISBN-10: 0781765196. ISBN-13: 978-0781765190. The textbook that has defined the field of immunology since 1984 is now in its thoroughly revised and updated Sixth Edition. This comprehensive, up-to-date text will be of interest to graduate students,post-doctoral fellows, basic and clinical immunolo...