2010 John Wiley & Sons Ltd, 299 p.
Introduction—Biofunctional Molecules and Organic Synthesis
What are biofunctional molecules?
Developmental stages of studies on biofunctional molecules
Small amounts of the samples are now suf?cient for the elucidation of the structures of biofunctional molecules
Why must biofunctional molecules be synthesized?
How can we synthesize biofunctional molecules?
What kind of knowledge and techniques are necessary to synthesize
Synthesis of Phytohormones, Phytoalexins and Other Biofunctional Molecules of Plant Origin
Phytohormones
Phytoalexins
Plant allelochemicals
Other bioactive compounds of plant origin
Synthesis of Insect Bioregulators Other than Pheromones
Insect juvenile hormones
Insect antifeedants
Insect repellents
Synthesis of Pheromones
What are pheromones?
Methods for enantioselective synthesis
Why is it meaningful to synthesize enantiopure pheromones?
Chiral pheromones whose single enantiomers show bioactivity
Chiral pheromones whose stereochemistry–bioactivity relationships are diverse and complicated
Signi?cance of chirality in pheromone science
Synthesis of Biofunctional Molecules of Microbial Origin
Microbial hormones
Antibiotics
Other bioactive metabolites of micro-organisms
Synthesis of Marine Bioregulators, Medicinals and Related Compounds
Marine natural products of ecological importance such as antifeedants
Marine natural products of medicinal interest
Glycosphingolipids and sphingolipids of medical interest
Synthetic Examination of Incorrectly Proposed Structures of Biomolecules
Origin of incorrect or obscure structures
Structure fabrications of historical interest
Incorrect structures resulting from inappropriate use of puri?cation or analytical methods
Inappropriate structural proposal caused by problems in bioassay methods
Human errors are inevitable in chemistry, too
Conclusion—Science as a Human Endeavor
Small molecules are also beautiful
Continuous efforts may bring something meaningful
Can a scientist eventually have a hope in the future?
Introduction—Biofunctional Molecules and Organic Synthesis
What are biofunctional molecules?
Developmental stages of studies on biofunctional molecules
Small amounts of the samples are now suf?cient for the elucidation of the structures of biofunctional molecules
Why must biofunctional molecules be synthesized?
How can we synthesize biofunctional molecules?
What kind of knowledge and techniques are necessary to synthesize
Synthesis of Phytohormones, Phytoalexins and Other Biofunctional Molecules of Plant Origin
Phytohormones
Phytoalexins
Plant allelochemicals
Other bioactive compounds of plant origin
Synthesis of Insect Bioregulators Other than Pheromones
Insect juvenile hormones
Insect antifeedants
Insect repellents
Synthesis of Pheromones
What are pheromones?
Methods for enantioselective synthesis
Why is it meaningful to synthesize enantiopure pheromones?
Chiral pheromones whose single enantiomers show bioactivity
Chiral pheromones whose stereochemistry–bioactivity relationships are diverse and complicated
Signi?cance of chirality in pheromone science
Synthesis of Biofunctional Molecules of Microbial Origin
Microbial hormones
Antibiotics
Other bioactive metabolites of micro-organisms
Synthesis of Marine Bioregulators, Medicinals and Related Compounds
Marine natural products of ecological importance such as antifeedants
Marine natural products of medicinal interest
Glycosphingolipids and sphingolipids of medical interest
Synthetic Examination of Incorrectly Proposed Structures of Biomolecules
Origin of incorrect or obscure structures
Structure fabrications of historical interest
Incorrect structures resulting from inappropriate use of puri?cation or analytical methods
Inappropriate structural proposal caused by problems in bioassay methods
Human errors are inevitable in chemistry, too
Conclusion—Science as a Human Endeavor
Small molecules are also beautiful
Continuous efforts may bring something meaningful
Can a scientist eventually have a hope in the future?