Фармацевтика
Медицинские дисциплины
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Patel Ramesh N. (Ed.) Biocatalysis in the Pharmaceutical and Biotechnology Industries
Biocatalysis in the Pharmaceutical and Biotechnology Industries Edited by Ramesh N. Patel
Preface
There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals in a highly chemo-, regio-, and enantioselective manner. Chiral intermediates are in high demand from pharmaceutical, agricultural, and other biotechnological industries for the preparation of bulk drug substances or fine chemicals. Bulk drug compounds or other fine chemicals can be produced by chemical or chemo-enzymatic synthesis. The advantages of biocatalysis over chemical synthesis are that enzyme-catalyzed reactions are often highly enantio- and regioselective. They can be carried out at ambient temperature and atmospheric pressure, thus avoiding the use of more extreme conditions which could cause problems with isomerization, racemization, epimerization, and rearrangement. Microbial cells and enzymes derived from microbial cells can be immobilized and reused for many cycles. Biocatalysis includes fermentation, biotransformation by whole cells or enzyme-catalyzed transformations, cloning and expression of enzymes, and directed evolution of enzymes to improve selectivity, substrate specificity, and stability. Various chapters in this book are contributed by inteationally well-known scientists having many years of experience in different aspects of biocatalysis and biocatalytic applications in production of fine chemicals and chiral pharmaceutical intermediates.
This book contains 34 chapters with over 4000 references and more than 600 tables, equations, drawings, and micrographs. All the information cited in this book provides stateof- the-art knowledge and improves the ability of the reader to use different types of enzymatic reactions in synthesis of fine chemicals and chiral compounds and their application in biotechnological industries. Various chapters discuss the following important aspects in biocatalysis and its applications in various industries: Application of nitrilases and nitrile hydratases in synthesis of fine chemicals that describe cloning and expression of nitrilases and their use in production of chiral and achiral carboxylic acids, regioselective and chemoselective hydrolysis of nitriles, preparation of amides from nitriles, commercialized processes for preparation of nicotinamide, cyanovaleramide, acrylamide, and nitrile-containing polymers. Biocatalytic deracemization processes that include dynamic kinetic resolution, stereoinversion processes, and enantioconvergent processes to prepare chiral compounds such as amino acids, amines, alcohols, diols, and epoxides in theoretical 100% yields. Biocatalysis in pharmaceutical industries for synthesis of chiral intermediates and fine chemicals for chemoenzymatic synthesis of drugs such as anticancer, antiviral, antihypertensive, anticholesterol, anti-infective, anti-infammatory, antianxiety, and antipsychotic drugs. Methods for directed evolution of lipases and esterases, assay development and screening of mutants for selection in esterification, transesterification, acylation and acyl hydrolytic reactions, and use of improved enzymes in organic synthesis. Oxidative biocatalysis catalyzed by flavin-containing flavoprotein oxidases such as alcohol oxidases, amine oxidases, and sulfhydryl oxidases together with flavoprotein monooxygenases such as aromatic, heteroatom, and multicomponent monooxygenase in enzymatic oxygenation reactions.
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