
Environmental Encyclopedia 3
Flu pandemic
unusually high portion of the population) every 10–40 years.
The last influenza pandemic was the Hong Kong flu of
1968–69, which caused 700,000 deaths worldwide, and
killed 33,000 Americans. The influenza virus is highly muta-
ble, so each year’s flu outbreak presents the human body
with a slightly different virus. Because of this, people do not
build an immunity to influenza. Vaccines are successful in
protecting people against influenza, but vaccine manufactur-
ers must prepare a new batch each year, based on their
best supposition of which particular virus will spread. Most
influenza viruses originate in China, and doctors, scientists,
and public health officials closely monitor flu cases there
in order to make the appropriate vaccine. The two main
organizations tracking influenza are the Centers for Disease
Control (CDC) and the World Health Organization
(WHO). The CDC and other government agencies have
been preparing for a flu pandemic on the level of Spanish
flu since the early 1990s.
Spanish flu did not originate in Spain, but presumably
in Kansas, where the first case was recorded in March, 1918,
at the army base Camp Funston. It quickly spread across
the United States, and then to Europe with American sol-
diers who were fighting in the last months of World War
I. Infected ships brought the outbreak to India, New
Zealand, and Alaska. Spanish flu killed quickly. People often
died within 48 hours of first feeling symptoms. The disease
afflicted the lungs, and caused the tiny air sacs, called alveoli,
to fill with fluid. Victims were soon starved of oxygen, and
sometimes effectively drowned on the fluid clogging their
lungs. Children and old people recovered from the Spanish
flu at a much higher rate than young adults. In the United
States, the death rate from Spanish flu was several times
higher for men aged 25–29 than for men in their seventies.
Social conditions at the time probably contributed to
the remarkable power of the disease. The flu struck just at
the end of World War I, when thousands of soldiers were
moving from America to Europe and across that continent.
In a peaceful time, sick people may have gone home to bed,
and thus passed the disease only to their immediate family.
But in 1918, men with the virus were packed in already
crowded hospitals and troop ships. The unrest and devasta-
tion left by the war probably hastened the spread of Spanish
flu. So it is possible that if a similarly virulent virus were to
arise again soon, it would not be quite as destructive.
Researchers are concerned about a return of Spanish
flu because little is known about what made it so virulent.
The flu virus was not isolated until 1933, and since then,
there have been several efforts to collect and study the 1918
virus by exhuming graves in Alaska and Norway, where
bodies were preserved in permanently frozen ground. In
1997, a Canadian researcher, Kirsty Duncan, was able to
extract tissue samples from the corpses of seven miners who
566
had died of Spanish flu in October 1918 and were buried
in frozen ground on a tiny island off Norway. Duncan’s
work allowed scientists at several laboratories around the
world to do genetic work on the Spanish flu virus. But by
2002, there was still no conclusive agreement on what was
so different about the 1918 virus.
The influenza virus is believed to originate in migratory
water fowl, particularly ducks. Ducks carry influenza viruses
without becoming ill. They excrete the virus in their feces.
When their feces collect in water, other animals can become
infected. Domestic turkeys and chickens can easily become
infected with influenza virus borne by wild ducks. But most
avian (bird-borne) influenza does not pass to humans, or if
it does, is not particularly virulent. But other mammals too
can pick up influenza from either wild birds or domestic fowl.
Whales
,
seals
, ferrets, horses, and pigs are all susceptible to
bird-borne viruses. When the virus moves between
species
,
it may mutate. Human influenza viruses most likely pass
from ducks to pigs to humans. The 1918 virus may have
been a particularly unusual combination of avian and swine
virus, to which humans were unusually vulnerable.
Enacting controls on pig and poultry farms may be
an important way to prevent the rise of a new influenza
pandemic. Some influenza researchers recommend that pigs
and domestic ducks and chickens not be raised together.
Separating pigs and fowl at live markets may also be a sensible
precaution. With the concentration of poultry and pigs at
huge “factory” farms, it is important for farmers, veterinari-
ans, and public health officials to monitor for influenza. A flu
outbreak among chickens in Hong Kong in 1997 eventually
killed six people, but the epidemic was stopped by the quick
slaughter of millions of chickens in the area. Any action to
control flu of course must be an international effort, since
the virus moves rapidly without respect to national borders.
[Angela Woodward]
R
ESOURCES
P
ERIODICALS
Gladwell, Malcolm. “The Dead Zone.” New Yorker (September 29, 1997):
52–65.
Henderson, C. W. “Spanish Flu Victims Hold Clues to Fight Virus.”
Vaccine Weekly (November 29, 1999/December 6, 1999): 10.
Koehler, Christopher S. W. “Zeroing in on Zoonoses.” Modern Drug Dis-
covery 8, no. 4 (August 2001): 44–50.
Lauteret, Ronald L. “A Short History of a Tragedy” Alaska (November
1999): 21–23.
Pickrell, John. “Killer Flu with a Human-Pig Pedigree?” Science 292 (May
11, 2001): 1041.
Shalala, Donna E. “Collaboration in the Fight Against Infectious Diseases.”
Emerging Infectious Diseases 4, no. 3 (July/September 1998): 354.
Webster, Robert G. “Influenza: An Emerging Disease.” Emerging Infectious
Diseases 4, no. 3 (July-September 1998).