
662 Chapter 24
24.5  Valuing a Biotechnology Project
4
One of the interesting features of the biotech industry is the existence 
of highly valued fi rms that have no revenues. It is common understanding 
that the value of those fi rms is in their future cash fl ow opportunities. 
Therefore, understanding the translation of qualitative investment 
opportunities into quantitative valuation is of great importance when 
valuating those fi rms. In this section we use the real-option method to 
value a biotechnology project and to illustrate the application of the 
real-option approaches.
Consider the following story.
5
 A fi rm is considering the initiation of 
research into a new drug. It knows that there are three stages to the 
drug’s development:
1. In the discovery phase the fi rm does preliminary research about the 
viability of the idea. This research takes one year and costs $1,000 at 
the beginning of the year, with 50 percent probability that the results 
will be positive enough to proceed to the next stage of research.
2.  If the discovery phase yields success, then the drug goes into the clini-
cal phase, in which the drug is tested. This stage lasts one year, costs 
$2,000 at the beginning of the year, and with a probability of 30 percent 
yields enough positive results to proceed to the next stage.
3.  If the drug passes the clinical phase successfully, then it goes into the 
market stage, in which it is sold. This phase costs $15,000 per year (at the 
beginning of each year) and on average lasts fi ve years. On average, a 
successful drug can be expected to start the marketing phase with income 
of $20,000. This income grows with annual mean 10 percent and standard 
deviation σ = 100 percent.
The expected return on a project of this type is 25 percent. We assume 
that this is the cost of capital of the project in the case of a discounted-
cash-fl ow (DCF) valuation.
4.  A version of this example originally appeared in Benninga and Tolkowsky (2002).
5.  We have made the story simple enough to fi t an understandable spreadsheet. For a 
somewhat more complicated story in the same spirit, see Kellogg and Charnes 
(2000).