Kwak M. Self-assembled structures and applications of DNA hybrid materials

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Kwak M. Self-assembled structures and applications of DNA hybrid materials

Ph.D. Thesis, University of Groningen, 2011. - 192 p. - In chapter 1, it has been described that chemical DNA nanotechnology with a focus on the combination of nucleic acids with synthetic polymers is an emerging field especially in regard to materials and life sciences. In the next chapter, these soft matter DNA nanoparticles were employed for loading virus capsids that have recently gained great interest with potential drug delivery and gene therapy applications. In chapter 3, DNA diblock copolymers (DNA-b-PPO) were utilized to form mixed micelles together with Pluronic™ triblock architectures (PEO-b-PPO-b-PEO). A systematic study on DNA micelles was carried out in chapter
4. In chapter 5, "Polarizable DNA Nanoparticles", DNA block copolymer micelles with a polystyrene core and a single-stranded (ss) DNA shell were doped with ferrocene (Fc). The last chapter deals with the utilization of DBCs with the most promising nanomaterials, single-walled carbon nanotube (SWNT), for eventual incorporation into practical technologies.

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