InTech. 2011. 806 p.
Over the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research of the mechanisms of DNA repair is merging with clinical research, placing the action of the DNA repair pathways in the context of the whole organism. Such integrative approach enables understanding of the disease mechanisms and is invaluable in improving diagnostics and prevention, as well as designing better therapies. This book highlights the central role of DNA repair in human health and well-being. The reviews presented here, contain detailed descriptions of DNA repair pathways, as well as analysis of a large body of evidence addressing links between DNA damage repair and human health. They will be of interest to a broad audience, from molecular biologists working on DNA repair in any model system, to medical researchers.
Contents
Preface
DNA Repair Mechanisms
DNA Repair, Human Diseases and Aging
Double Strand Break Signaling in Health and Diseases
DNA Damage Repair and Cancer: The Role of RAD51 Protein and Its Genetic Variants
The Role of Error-Prone Alteative Non-Homologous End-Joining in Genomic Instability in Cancer
Nucleotide Excision Repair and Cancer
Recombinant Viral Vectors for Investigating DNA Damage Responses and Gene Therapy of Xeroderma Pigmentosum
DNA Repair and Cancer
DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy
DNA Repair, Cancer and Cancer Therapy
DNA Repair, Cancer and Cancer Therapy - The Current State of Art
Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment
Hypoxia Inhibits DNA Repair to Promote Malignant Progression
From the Molecular Biology to the Gene Therapy of a DNA Repair Syndrome: Fanconi Anemia
Fanconi Anemia/Brca Pathway and Head and Neck Squamous Cell Carcinomas
DNA Repair Deficiency Associated with Hematological Neoplasms
DNA Repair in Acute Myeloid Leukemia and Myelodysplastic Syndromes
Therapeutic Modulation of DNA Damage and Repair Mechanisms in Blood Cells
DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms
DNA Mismatch Repair (MMR) Genes and Endometrial Cancer
Human Apurinic/Apyrimidinic Endonuclease is a Novel Drug Target in Cancer
Disruption of Protein–DNA Interactions: An Opportunity for Cancer Chemotherapy
Pharmacogenomic Approach of Telomerase in Cancer: Importance of End Zone Variability
Differential Effects of the G-Quadruplex Ligand 360A in Human Normal and Cancer Cells
Pharmacogenetics of Cancer and DNA Repair Enzymes
DNA Repair and Aging
Involvement of Histone PTMs in DNA Repair Processes in Relation to Age-Associated Neurodegenerative Disease
Transcriptional Functions of DNA Repair Proteins Involved in Premature Aging
DNA Damage and Disease
DNA Damage and mRNA Levels of DNA Base Excision Repair Enzymes Following H2O2 Challenge at Different Temperatures
Relationship Between DNA Damage and Energy Metabolism: Evidence from DNA Repair Deficiency Syndromes
Infection, Inflammation and DNA Repair
The Role of DNA Repair Pathways in Adeno-Associated Virus Infection and Viral Genome Replication / Recombination / Integration
Integration of the DNA Damage Response with Innate Immune Pathways
Non-Steroidal Anti-Inflammatory Drugs, DNA Repair and Cancer
Inhibition of DNA Polymerase ?, a DNA Repair Enzyme, and Anti-Inflammation: Chemical Knockout Analysis for DNA Polymerase ? Using Curcumin Derivatives
Over the past decades, great advances have been made in understanding the cellular DNA repair pathways. At the same time, a wealth of descriptive knowledge of human diseases has been accumulated. Now, the basic research of the mechanisms of DNA repair is merging with clinical research, placing the action of the DNA repair pathways in the context of the whole organism. Such integrative approach enables understanding of the disease mechanisms and is invaluable in improving diagnostics and prevention, as well as designing better therapies. This book highlights the central role of DNA repair in human health and well-being. The reviews presented here, contain detailed descriptions of DNA repair pathways, as well as analysis of a large body of evidence addressing links between DNA damage repair and human health. They will be of interest to a broad audience, from molecular biologists working on DNA repair in any model system, to medical researchers.
Contents
Preface
DNA Repair Mechanisms
DNA Repair, Human Diseases and Aging
Double Strand Break Signaling in Health and Diseases
DNA Damage Repair and Cancer: The Role of RAD51 Protein and Its Genetic Variants
The Role of Error-Prone Alteative Non-Homologous End-Joining in Genomic Instability in Cancer
Nucleotide Excision Repair and Cancer
Recombinant Viral Vectors for Investigating DNA Damage Responses and Gene Therapy of Xeroderma Pigmentosum
DNA Repair and Cancer
DNA Damage, Repair and Misrepair in Cancer and in Cancer Therapy
DNA Repair, Cancer and Cancer Therapy
DNA Repair, Cancer and Cancer Therapy - The Current State of Art
Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment
Hypoxia Inhibits DNA Repair to Promote Malignant Progression
From the Molecular Biology to the Gene Therapy of a DNA Repair Syndrome: Fanconi Anemia
Fanconi Anemia/Brca Pathway and Head and Neck Squamous Cell Carcinomas
DNA Repair Deficiency Associated with Hematological Neoplasms
DNA Repair in Acute Myeloid Leukemia and Myelodysplastic Syndromes
Therapeutic Modulation of DNA Damage and Repair Mechanisms in Blood Cells
DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms
DNA Mismatch Repair (MMR) Genes and Endometrial Cancer
Human Apurinic/Apyrimidinic Endonuclease is a Novel Drug Target in Cancer
Disruption of Protein–DNA Interactions: An Opportunity for Cancer Chemotherapy
Pharmacogenomic Approach of Telomerase in Cancer: Importance of End Zone Variability
Differential Effects of the G-Quadruplex Ligand 360A in Human Normal and Cancer Cells
Pharmacogenetics of Cancer and DNA Repair Enzymes
DNA Repair and Aging
Involvement of Histone PTMs in DNA Repair Processes in Relation to Age-Associated Neurodegenerative Disease
Transcriptional Functions of DNA Repair Proteins Involved in Premature Aging
DNA Damage and Disease
DNA Damage and mRNA Levels of DNA Base Excision Repair Enzymes Following H2O2 Challenge at Different Temperatures
Relationship Between DNA Damage and Energy Metabolism: Evidence from DNA Repair Deficiency Syndromes
Infection, Inflammation and DNA Repair
The Role of DNA Repair Pathways in Adeno-Associated Virus Infection and Viral Genome Replication / Recombination / Integration
Integration of the DNA Damage Response with Innate Immune Pathways
Non-Steroidal Anti-Inflammatory Drugs, DNA Repair and Cancer
Inhibition of DNA Polymerase ?, a DNA Repair Enzyme, and Anti-Inflammation: Chemical Knockout Analysis for DNA Polymerase ? Using Curcumin Derivatives