Hiyama K. Telomeres and telomerase in cancer

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размер 15.01 МБ
добавлен 20 апреля 2011 г.

Книга - Telomeres and telomerase in cancer, Keiko Hiyama, 2009.
Basic Background.
Telomeres and Telomerase in Humans.
Telomere-Binding Proteins in Humans.
Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms.
Telomere Dysfunction and the DNA Damage Response.
Alteative Lengthening of Telomeres in Human Cells.
Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer.
Telomeres and Telomerase in Human Cancers.
Role of Telomeres and Telomerase in Cancer.
Diagnostic Value I: Solid Tumors.
Diagnostic Value II: Hematopoietic Malignancies.
Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors.
Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors.
Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors.
Therapeutic Targets and Drugs IV: Telomerase-Speci?c Gene and Vector-Based Therapies for Human Cancer.
Experimental Protocols.
Protocol I: Telomerase Activity and Telomerase Expression.
Protocol II: Importance and Methods of Telomere G-Tail Length Quanti?cation.
Protocol III: Detection of Alteative Lengthening of Telomeres.

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