PERIODONTAL SURGERY: ACCESS THERAPY • 539
and have therefore replaced esters as the "gold stan-
dard" for dental local anesthetics.
Due to the specific need for bone penetration, den-
tal local anesthetics contain high concentrations of the
active agent. Although most amide local anesthetics
may cause local vasoconstriction in low concentra-
tions, the clinically used concentrations in dental so-
lutions will cause an increase in the local blood flow.
Significant clinical effects of this induced vasodilation
are an increased rate of absorption, thus decreasing
the duration of anesthesia. Major benefits can there-
fore be obtained by adding relatively high concentra-
tions of vasoconstrictors (e.g. epinephrine > 1:200 000
or > 5 mg/ml) to dental local anesthetic solutions; the
duration is considerably prolonged, the depth of an-
esthesia may be enhanced and the peak concentra-
tions of the local anesthetic in blood can be reduced.
Furthermore, in periodontal surgery, incorporation of
adrenergic vasoconstrictors into the local anesthetic is
of considerable value in keeping bleeding to a mini-
mum during surgery (avoiding considerable blood
loss, making it possible to visualize the surgical site
and thus with intact surgical quality shorten the time
spent on the procedure). As a matter of fact, the use of
a dental local anesthetic without a vasoconstrictor
during a periodontal surgical procedure is counter-
productive because the vasodilating properties of
such a local anesthetic will increase the bleeding in the
area of surgery.
Vasoconstrictors and local
hemostasis
Epinephrine is the vasoconstrictor of choice for local
hemostasis and is most commonly used in a concen-
tration of 1:80 000 (12.5 mg/ml). However, 1:100 000
epinephrine also provides excellent hemostasis and
most periodontists are unable to detect a clinical dif-
ference between the two concentrations. It therefore
seems prudent to use the least concentrated form of
epinephrine that provides clinically effective hemo-
stasis (i.e. the 1:100 000 concentration).
Although the cardiovascular effects of the usually
small amounts of epinephrine used during a peri-
odontal surgical procedure are of little practical con-
cern in most individuals, accidental intravascular in-
jections, unusual patient sensitivity and unantici-
pated drug interactions (or excessive doses) can result
in potentially serious outcomes. It must also be under
-
stood that the use of epinephrine for hemostasis dur-
ing periodontal surgery has some potential draw-
backs. Epinephrine will produce a rebound vasodila-
tion after the vasoconstriction has worn off, leading to
increased risk for bleeding in the immediate postop-
erative period. There is a greater potential for such
undesirable delayed hemorrhage following the use of
1:80.000 epinephrine than after the use 1:100 000.
Postoperative pain may increase and wound heal-
ing may be delayed when adrenergic vasoconstrictors
are used because of local ischemia with subsequent
tissue acidosis and accumulation of inflammatory me
-
diators. Furthermore, the possibility of an ischemic
necrosis of surgical flaps infiltrated with an adrenergic
vasoconstrictor (especially if norepinephrine is used
instead of epinephrine) cannot be discounted. For
these reasons as well as because of the possibility of
systemic reactions alluded to above, dental local an-
esthetics containing adrenergic vasoconstrictors for
hemostasis should be infiltrated
only
as needed and
not
merely from habit.
Felypressin, another commonly used vasoconstric-
tor, appears to act preferentially on the venous side of
the microcirculation and is not very active in constrict
-
ing the arteriolar circulation. Felypressin is therefore
not nearly as effective as adrenergic vasoconstrictors
in limiting hemorrhage during a surgical procedure.
Individual variability in response to dental local
anesthetics
Although it is possible for the periodontist to choose
from a broad spectrum of dental local anesthetics to
achieve the expected clinical action, there are a num-
ber of other factors (i.e. not related to the drug) that
can affect the drug action in a single patient.
During clinical conditions the variability in re-
sponse to dental local anesthetics administered can be
expected to be great, for example with regard to depth
and duration of anesthesia. The reason for the great
variation has not been adequately explained but has
to be accepted as it may have significant implications
in periodontal surgical procedures. A list of possible
factors that may cause anesthetic failures include:
•
Accuracy in administration of the drug
•
Anatomic variation between patients (e.g. in elderly
patients with bone resorption)
•
Status of the tissues at the site of injection (
vascular
ity, inflammation)
•
General condition of patient
•
Psychologic factors
Inaccuracy in administration is a major factor causing
anesthetic failures. Although not particularly signifi-
cant in infiltration anesthesia, the mandibular block is
a prime example of a technique in which duration of
anesthesia is greatly influenced by accuracy of injec-
tion.
The general condition of the patient as well as
psychologic factors may also affect the anticipated
duration of action. Infection, stress or pain will usually
lead to decreased duration of anesthesia, while an
increase in the patient's own defense mechanisms
against pain perception by, for example, release of
endogenous endorphins, may provide improved
depth and/or duration of anesthesia.
Techniques for anesthesia in periodontal surgery
Injections of dental local anesthetics prior to a peri-
odontal surgical procedure may be routine for the
dentist, but are often a most unpleasant experience for
the patient. Reassurance and psychologic support are
essential and will increase the patient's confidence in