Scheffler Immo E. Mitochondria
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COLOR PLATES
A
B
Figure 5.18 X - ray structure of complex IV. (A) Side view showing the transmembrane
segments of the various subunits; matrix side at the bottom. (B) View from the cytosolic
side. (The photographs were kindly provided by Dr. S. Yoshikawa of the Himeji Insti-
tute of Technology, Hyogo, Japan. From reference 157 with permission.)
COLOR PLATES
A
B
Figure 5.19 X - ray structure of complex IV. Stereo images of the C
α
- backbone tracings.
(A) Subunits I, II, and III. (B) Subunits IV, Va, Vb, VIa, Vib, Vic, VIIa, VIIb, and VIII.
(The photographs were kindly provided by Dr. S. Yoshikawa of the Himeji Institute of
Technology, Hyogo, Japan. From reference 157 with permission.)
COLOR PLATES
Figure 5.21 (A) Schematic view of complex IV with the four essential subunits (155) . (B) The proposed D
and K pathways for the entry of protons to form water and to be pumped across the membrane. The path
from the region of the hemes to the outside is still poorly defi ned. (From reference 155 with permission.)
A
SU II
SU I
SU III
SU IV
P side
N side
Cu
A
Cu
B
heme a
3
heme a
Y288
T359
S299
K362
E101
II
E286
Mg
2+
D pathway
K pathway
D132
N139
N121
S201
e
−
H
+
H
+
B
COLOR PLATES
AB
CD
α
DP
β
DP
β
TP
α
TP
α
E
β
E
γ
β
E
α
TP
α
TP
β
DP
α
E
β
TP
α
DP
β
E
α
E
β
DP
β
TP
α
DP
γ
β
DP
α
E
α
DP
β
TP
β
E
α
TP
γ
β
TP
α
DP
α
TP
β
E
β
DP
α
E
γ
Figure 5.27 X - ray structure of the F
1
subcomplex of complex V. (A) Ribbon model
showing the α
3
β
3
hexamer and the γ subunit constituting the rotating shaft. (B – D)
Three different views of the shaft ( γ subunit) and side views of two opposite α and β
subunits. The image emphasizes the asymmetry and the different contacts made by each
of the six subunits with the central shaft. (From reference 263 with permission.)