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Designing your experiment
We said earlier that you need to randomly assign subjects to experiments. But what’s
the best way of doing this?
Completely randomized design
One option is to use a completely randomized design. For
this, you literally assign treatments to subjects at random. If
we were to conduct an experiment testing the effect of doses
of SnoreCull on snorers, we would randomly assign snorers to
particular treatment groups. As an example, we could give half
of the snorers a placebo and the other half a single dose of
SnoreCull.
Completely randomized design is similar to simple random
sampling. Instead of choosing a sample at random, you assign
treatments at random.
Randomized block design
Another option is to use randomized block design. For
this, you divide the subjects into similar groups, or blocks.
As an example, you could split the snorers into males and
females. Within each block, you assign treatments at random,
so for each gender, you could give half the snorers a dose of
SnoreCull and give the other half a placebo. The aim of this
is to minimize confounding, as it reduces the effect of gender.
Randomized block design is similar to stratified random
sampling. Instead of splitting your population into strata, you
split your subjects into blocks.
Matched pairs design
Matched pairs design is a special case of randomized
block design. You can use it when there are only two
treatment conditions and subjects can be grouped into like
pairs. As an example, the SnoreCull experiment could have
two treatment conditions, to give a placebo or to give a
single dose, and snorers could be grouped into similar pairs
according to gender and age. You then give one of each
pair a placebo, and the other a dose of SnoreCull. If one
pair consisted of two men aged 30, for instance, you would
give one of the men a placebo and the other man a dose of
SnoreCull.
Placebo SnoreCull
500 500
If there were 1,000 subjects, we
could give half a placebo and the
other half a dose of SnoreCull
Placebo SnoreCull
Male
250 250
Female
250 250
If there were 500 men and 500
women, we could give half of each
gender a placebo and the other
half a dose of SnoreCull
Placebo SnoreCull
Male 30
1 1
Male 30
1 1
Female 30
1 1
Female 30
1 1
...
... ...
You could also form matched pairs using
gender and age to negate confounding due to
these variables.